Drug interactions of some commonly used drugs in dermatology.

Table Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions of some commonly used drugs in dermatology Drug interactions leading to serious adverse effects are to be cautiously watched for when multiple drugs are used simultaneously. 1 It is important for the physician to be aware of these interactions. Although in many instances the adverse interaction does not reach a magnitude of recognizable clinical expression, rarely it can result in a serious adverse outcome. Adverse drug interactions may lead to increased toxicity, decreased efficacy or both. The possibility of interaction with non-prescription drugs, herbal or alternative medicines or food should also be borne in mind. 2 Increased risk of drug induced toxicity or therapeutic failure can occur when a new drug is added to a treatment regimen. It is impossible to remember all possible drug interactions. A ready to refer checklist is useful as a handy reference. Some of the commonly used drugs in dermatology and their interactions, resultant clinical effect and possible underlying mechanisms are given in Table 1. Table 2 lists the drugs with their relative risk for inducing interactions. How to cite this article: Cyriac MJ. Drug interactions of some commonly used drugs in dermat ology. Table 1: Drug interactions of some commonly used drugs Drug Interacting drug Adverse effect Remarks Theophylline toxicity CNS depression Digoxin toxicity CNS depression Ergotism Bleeding Nephrotoxicity Rhabdomyolysis Cardiac arrhythmias Cardiac arrhythmias Cardiac arrhythmias Valproate toxicity Theophylline toxicity Decreased antibiotic levels Decreased antibiotic levels Phenytoin toxicity Hypoglycemia Digoxin toxicity Bleeding Precipitates seizures Erythromycin/Clarithromycin Fluoroquinolones Tetracycline Trimethoprim-sulfamethoxazole Theophylline Carbamazepine Digoxin Triazolam Ergotamine Warfarin Cyclosporine/Tacrolimus Statins Astemizole/Terfenadine Cisapride Pimozide Sodium valproate Theophylline Antacid/sucralfate Antacid/sucralfate Phenytoin Oral hypoglycemics Digoxin Warfarin